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Moreover, Cyp2e1-/- mice showed resistance to the APAP high dose-associated hepatotoxicity, whereas human CYP2E1 transgenic mice were susceptible, suggesting that CYP2E1 is the major P450 enzyme participating in APAP activation ( via O-glucuronidation (50%70%) and O-sulfation (approximately 25%) pathways and forms the corresponding conjugates that can be easily excreted by the kidney

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In other words, glutathione doesn't work solely for the skin

change in mean fasting plasma glucose (FPG) at Week 30

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